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Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein.
Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Wong JM, de Souza R, Emam A, Parker TL, Vidgen E, Lapsley KG, Trautwein EA, Josse RG, Leiter LA, Connelly PW
JAMA 2003 Jul 23;290(4):502-10.
abstract (from PubMed)

In this study, 55 hyperlipidemic subjects were randomized to one of three diets for four weeks:

Subjects were provided with all of the foods on the diets, except for fruits and vegetables.

After 4 weeks, the vegetarian diet alone produced a minor improvement in lipids and C-reactive protein. In the vegetarian plus statin diet and in the vegetarian portfolio diets, there were much greater and similar improvements in lipid profiles and in C-reactive protein levels.

Weights and blood pressure did not differ significantly in the groups.

The authors conclude that an intervention including the addition of soy protein, soluble fiber, plant sterols and walnuts provides significant cholesterol-lowering benefits.


Initial CRP values?

September 30, 2003

In this study, the effect on CRP values seemed at least as significant as the effect on lipids. However, it is a bit troubling to me to see that the initial CRP values were very different.

Although the authors state that there was no significant difference in baseline blood values, they do not list CRP values in the table that details baseline characteristics. If baseline CRP was significantly lower in the conventional diet group, this could be responsible, in part, for the markedly reduced lowering of CRP in this group.

posted on 2003-09-30 20:01:29 by
Michael Jacobson, MD, MPH

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