Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Wong JM, de Souza R, Emam A, Parker TL, Vidgen E, Lapsley KG, Trautwein EA, Josse RG, Leiter LA, Connelly PW
JAMA 2003 Jul 23;290(4):502-10.
abstract (from PubMed)
In this study, 55 hyperlipidemic subjects were randomized to one of three diets for four weeks:
- a low-saturated fat, vegetarian diet, including dairy protein
- the same vegetarian diet, plus 20 mg lovastatin daily
- a vegetarian "portfolio" diet, with soy protein (around 50 g/day) replacing the dairy protein and with addition of soluble fiber (oats, barley and psyllium), almonds (around 35 g/day) and plant sterols
After 4 weeks, the vegetarian diet alone produced a minor improvement in lipids and C-reactive protein. In the vegetarian plus statin diet and in the vegetarian portfolio diets, there were much greater and similar improvements in lipid profiles and in C-reactive protein levels.
- In the vegetarian diet group, total cholesterol decreased from 246 mg/dl to 231; LDL from 166 to 152 (-8%); HDL from 46 to 41 and CRP from 1.36 to 1.08
- In the vegetarian plus statin group, total cholesterol decreased from 256 mg/dl to 197; LDL from 172 to 117 (-32%); HDL from 46 to 44 and CRP from 3.40 to 2.05
- In the vegetarian portfolio diet group, total cholesterol decreased from 268 mg/dl to 209; LDL from 178 to 126 (-29%); HDL from 46 to 43 and CRP from 2.39 to 1.13
The authors conclude that an intervention including the addition of soy protein, soluble fiber, plant sterols and walnuts provides significant cholesterol-lowering benefits.
Initial CRP values?September 30, 2003
In this study, the effect on CRP values seemed at least as significant as the effect on lipids. However, it is a bit troubling to me to see that the initial CRP values were very different.
Although the authors state that there was no significant difference in baseline blood values, they do not list CRP values in the table that details baseline characteristics. If baseline CRP was significantly lower in the conventional diet group, this could be responsible, in part, for the markedly reduced lowering of CRP in this group.
posted on 2003-09-30 20:01:29 by
Michael Jacobson, MD, MPH
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